Summary
Optical coherence tomography (OCT) is an optical imaging method that allows for in-vivo, non-invasive imaging of the structure and vasculature of biological tissue. Commercially available, clinical OCT systems utilize point-scanning method to acquire volumetric images over a large surface with typical frame rates of ~ 30 frames/ second. Since living biological tissue is constantly moving due to breathing, heart rate, muscle twitch, etc., OCT images acquired with the point-scanning method are compromised by motion-related image artefacts. In this project, we propose to build an ultra-fast OCT system based on a line-scanning method, capable of resolving this issue. By combining high resolution (<2-micron) with high imaging speed (2,500 frames / second), the line-scanning OCT technology will be able to generate in-vivo and non-invasively volumetric images of biological tissue down to the sub-cellular level; map in 3D the blood vasculature and measure precisely the blood flow; and measure the functional response of neural tissues to external stimuli. We plan to use the new OCT system to image the healthy and pathological human cornea and limbus, with the ultimate the goal of improving early diagnostics and monitoring of the effectiveness of treatment of potentially blinding corneal and limbal diseases.
Related Content

Tuning Spin-Exchange Interactions in Low-Dimensional Metal Halide Perovskites: A New Class of Semiconductor Quantum Materials
Summary Leakage current in electronic components is one of the limiting factors for the performance of conventional computers which use charges and currents as physical information carriers. Spintronics offers an alternative by using electron spin for information transfer, processing and storage, enabling the design of non-volatile computer memory and more energy-efficient electronic devices. In this […]
October 1, 2019
Fabrication of Ultra Low Noise RF SQUID Amplifiers
A superconducting quantum interference device (SQUID) is an extremely sensitive magnetic field detector.
June 1, 2017
Quantum Sensing Applications using Quantum Communication Technology
Summary The Quantum Encryption and Science Satellite provides a platform to develop and deploy quantum sensing and metrology via photonic channels. This project will build upon ‘free-space’ quantum communication technology and explore new approaches and methods to advance two primary applications: quantum-enhanced telescopes, and spectroscopic sensing for methane detection in the atmosphere. For the […]
December 8, 2018

Extensible Technology for a Medium-Scale Superconducting Quantum Processor
Summary Superconducting quantum bits, or qubits, use circuits made from superconducting materials to harness quantum mechanical states. These devices contain many atoms, but can behave as simple, controllable qubits. We are building technologies for the control and measurement of superconducting qubits to enable the first demonstration of an extensible, medium-scale quantum processor. Our approach […]
November 28, 2016