Summary
Optical coherence tomography (OCT) is an optical imaging method that allows for in-vivo, non-invasive imaging of the structure and vasculature of biological tissue. Commercially available, clinical OCT systems utilize point-scanning method to acquire volumetric images over a large surface with typical frame rates of ~ 30 frames/ second. Since living biological tissue is constantly moving due to breathing, heart rate, muscle twitch, etc., OCT images acquired with the point-scanning method are compromised by motion-related image artefacts. In this project, we propose to build an ultra-fast OCT system based on a line-scanning method, capable of resolving this issue. By combining high resolution (<2-micron) with high imaging speed (2,500 frames / second), the line-scanning OCT technology will be able to generate in-vivo and non-invasively volumetric images of biological tissue down to the sub-cellular level; map in 3D the blood vasculature and measure precisely the blood flow; and measure the functional response of neural tissues to external stimuli. We plan to use the new OCT system to image the healthy and pathological human cornea and limbus, with the ultimate the goal of improving early diagnostics and monitoring of the effectiveness of treatment of potentially blinding corneal and limbal diseases.
Related Content
Plasmon Control of Quantum States in Semiconductor Nanocrystals
Summary Thanks to the light-induced collective oscillations of free charges at the boundary between a conducting material and a dielectric, known as surface plasmon resonance, metallic nanostructures can exhibit strong light absorption and scattering. The sensitivity of these resonances to the local environment and shape of the metallic structures allows them to be used, […]
March 21, 2018
Cryo-CMOS to Control and Operate 2D Fault-Tolerant Qubit Network
Summary Large-scale, fault-tolerant quantum computation requires precise and stable control of individual qubits. This project will use complementary metal-oxide-semiconductor (CMOS) technology to provide a cost-effective scalable platform for reliable and high-density control infrastructure for silicon spin qubits. We will use sub-micron CMOS technology to address device and circuit-level challenges and explore the integration of […]
June 14, 2018
Inverse Photoemission Spectroscopy of Quantum Materials
Summary Quantum materials that exhibit strong electron correlations lead to phenomena, such as superconductivity and topologically protected states, that are important for quantum computation, sensing, and other applications. For example, we may utilize symmetry protected topological states to make qubits that are robust against decoherence, while advances in high temperature superconductors may significantly reduce […]
September 20, 2018
QuantumIon: an open-access quantum computing platform
Summary Trapped ions are one of the most advanced technologies for quantum computing, offering multi-qubit control in a universal quantum computing architecture and the ability to perform calculations with unprecedented precision. In this project we construct a shared trapped-ion quantum computing platform, QuantumIon, that will enable a broader and interdisciplinary scientific community to access an […]
September 9, 2019