Summary
Optical coherence tomography (OCT) is an optical imaging method that allows for in-vivo, non-invasive imaging of the structure and vasculature of biological tissue. Commercially available, clinical OCT systems utilize point-scanning method to acquire volumetric images over a large surface with typical frame rates of ~ 30 frames/ second. Since living biological tissue is constantly moving due to breathing, heart rate, muscle twitch, etc., OCT images acquired with the point-scanning method are compromised by motion-related image artefacts. In this project, we propose to build an ultra-fast OCT system based on a line-scanning method, capable of resolving this issue. By combining high resolution (<2-micron) with high imaging speed (2,500 frames / second), the line-scanning OCT technology will be able to generate in-vivo and non-invasively volumetric images of biological tissue down to the sub-cellular level; map in 3D the blood vasculature and measure precisely the blood flow; and measure the functional response of neural tissues to external stimuli. We plan to use the new OCT system to image the healthy and pathological human cornea and limbus, with the ultimate the goal of improving early diagnostics and monitoring of the effectiveness of treatment of potentially blinding corneal and limbal diseases.
Related Content
Quantum Computational Resources in the Presence of Symmetry
Summary Fault-tolerance is essential to the performance of quantum technologies, but known schemes are extremely resource intensive. Thus, improving existing schemes or inventing new schemes is of central importance. This joint project is based on the realization that fault-tolerance schemes make use of symmetries in fundamental ways, and that studying the problem of fault tolerance […]
March 13, 2019
Quantum Sensing with Small Quantum Systems
Summary There are small quantum systems over which we have very good control and which have long lifetimes. Examples include the phosphorous (P) defect in silicon (Si) and the nitrogen vacancy (NV) defect in diamond. With P defect in Si, we focus on improving our understanding of the hyperpolarization mechanism to better enable engineering of […]
December 1, 2016
Two-Dimensional Quantum Materials and Heterostructures
Two-dimensional (2D) layers just one atom thick can be stripped from certain materials, such as graphene.
June 1, 2017
Development of Terahertz Polariton Lasers
Theoretical and experimental results show that the polariton lasing mechanism is a promising basis for a compact, efficient source of terahertz radiation.
July 1, 2017